Innovative Methodology Artificial Dirt: Microfluidic Substrates for Nematode Neurobiology and Behavior
نویسندگان
چکیده
S. R. Lockery, K. J. Lawton, J. C. Doll, S. Faumont, S. M. Coulthard, T. R. Thiele, N. Chronis, K. E. McCormick, M. B. Goodman, and B. L. Pruitt Department of Biology, University of Oregon, Eugene, Oregon; Department of Mechanical Engineering and Department of Molecular and Cellular Physiology, Stanford University, Stanford, California; and Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan
منابع مشابه
Artificial dirt: microfluidic substrates for nematode neurobiology and behavior.
With a nervous system of only 302 neurons, the free-living nematode Caenorhabditis elegans is a powerful experimental organism for neurobiology. However, the laboratory substrate commonly used in C. elegans research, a planar agarose surface, fails to reflect the complexity of this organism's natural environment, complicates stimulus delivery, and is incompatible with high-resolution optophysio...
متن کاملMicrofluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans.
The nematode Caenorhabditis elegans is a widely adopted model organism for studying various neurobiological processes at the molecular and cellular level in vivo. With a small, flexible, and continuously moving body, the manipulation of C. elegans becomes a challenging task. In this review, we highlight recent advances in microfluidic technologies for the manipulation of C. elegans. These new f...
متن کاملEntrepreneurship policy and innovative indicators of industrial companies: Evaluation by MCDM and ANN Methods
The present paper presented a methodology for prioritizing the innovative and entrepreneurial indicators using Multi Criteria Decision Making (MCDM) and Artificial Neural Networks (ANNs), taking into account three individual, organizational and cultural dimensions simultaneously in decision making procedure. This methodology has two main advantages: first, the speed of operation in the accounti...
متن کاملEvaluation of a nanosuspension formulation prepared through microfluidic reactors for pulmonary delivery of budesonide using nebulizers
This study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. The size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM). Processing/formulation parameters for formation of the nanoparticles were studied to determine their effects o...
متن کاملEvaluation of a nanosuspension formulation prepared through microfluidic reactors for pulmonary delivery of budesonide using nebulizers
This study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. The size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM). Processing/formulation parameters for formation of the nanoparticles were studied to determine their effects o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008